Wade Wilson (Ryan Reynolds) is a former Special Forces operative who now works as a mercenary. His world comes crashing down when evil scientist Ajax (Ed Skrein) tortures, disfigures and transforms him into Deadpool. The rogue experiment leaves Deadpool with accelerated healing powers and a twisted sense of humor. With help from mutant allies Colossus and Negasonic Teenage Warhead (Brianna Hildebrand), Deadpool uses his new skills to hunt down the man who nearly destroyed his life.
Peter Quill and his fellow Guardians are hired by a powerful alien race, the Sovereign, to protect their precious batteries from invaders. When it is discovered that Rocket has stolen the items they were sent to guard, the Sovereign dispatch their armada to search for vengeance. As the Guardians try to escape, the mystery of Peter's parentage is revealed.